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| Prof Andreas Greinacher |
A German blood expert has conducted research that he says sheds light on why the Johnson & Johnson and AstraZeneca vaccines have triggered rare but serious blood clot conditions in a few vaccine recipients.
Andreas Greinacher, a researcher at the University of Greifswald, believes so-called viral vector vaccines could cause an autoimmune response that leads to blood clots in a small number of people. He believes that reaction could be tied to stray proteins and a preservative used in the vaccines.
“We strongly support raising awareness of the signs and symptoms of this very rare event, and we are currently exploring a potential collaboration with Dr. Greinacher,” a Johnson & Johnson spokesman told the Wall Street Journal.
Related Links:
EMA: AstraZeneca Covid19 Vaccine causes serious rare ADEs - https://european-biotechnology.com/up-to-date/latest-news/news/ema-azd1222-causes-serious-rare-ades.html
Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination
https://www.nejm.org/doi/full/10.1056/NEJMoa2104840
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VACCINE INGREDIENTS
Ingredients of AstraZeneca Vaccine:
Recombinant, replication-deficient chimpanzee adenovirus vector — active ingredient
Histidine — amino acid
Histidine hydrochloride monohydrate — amino acid salt
Sodium chloride — salt
Magnesium chloride hexahydrate — salt
Disodium edetate (EDTA) — salt
Sucrose — sugar
Ethanol absolute — alcohol
Polysorbate 80 — surfactant
Water
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Ingredients of Pfizer-Biontech Vaccine
Nucleoside-modified messenger RNA — active ingredient
((4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl) bis(2-hexyldecanoate) (ALC-0315) — lipid casing
2-[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide (ALC-0159) — lipid casing
Distearoylphosphatidylcholine (DSPC) — lipid casing
Cholesterol — lipid casing
Potassium chloride — salt
Monobasic potassium phosphate — salt
Sodium chloride — salt
Dibasic sodium phosphate dihydrate — salt
Sucrose — sugar
Water for injections
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Ingredients of Moderna Vaccine
Messenger ribonucleic acid (mRNA),
Lipids (SM-102, polyethylene glycol [PEG] 2000 dimyristoyl glycerol [DMG],
cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphocholine [DSPC]),
tromethamine,
tromethamine hydrochloride,
acetic acid,
sodium acetate trihydrate,
sucrose.
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Johnson & Johnson's (the Janssen) COVID-19 Vaccine includes the following ingredients:
Recombinant, replication-incompetent adenovirus type 26 expressing the SARS-CoV-2 spike protein,
citric acid
monohydrate,
trisodium citrate dihydrate,
ethanol,
2-hydroxypropyl-β-cyclodextri n (HBCD),
polysorbate-80,
sodium chloride.
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Sputnik V Ingredients
The Gam-COVID-Vac is a two-vector vaccine. The active component for both vectors is a modified (recombinant) replication-defective adenovirus of a different serotype (Serotype 26 containing (1.0 ± 0.5) × 1011 particles of gene for the first vaccination and serotype 5 containing (1.0 ± 0.5) × 1011 particles of gene for the second vaccination), which has been modified to include the spike protein-expressing gene of SARS-CoV-2.
The other ingredients are the same, both quantitatively and qualitatively, in the two components.
- Tris(hydroxymethyl)aminomethane
- Sodium chloride (salt)
- Sucrose (sugar)
- Magnesium chloride hexahydrate
- Disodium EDTA dihydrate (buffer)
- Polysorbate 80
- Ethanol 95%
- Water
No adjuvants and no other components or ingredients should be included in the vaccine.
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Additional Notes
Salts such as sodium chloride to keep the vaccine solution stable at a particular pH.
sucrose (table sugar) in the Pfizer vaccine protect the formula at sub-zero temperatures.
the compound called polyethylene glycol (PEG) forms part of the lipid casing
The AstraZeneca option contains ethanol absolute and histidine, substances work together to "mop up" free radicals that would otherwise contribute to the adenovirus degrading over time, and the vaccine losing potency.
AstraZeneca has an additive called Polysorbate 80. Polysorbate 80 is a non-ionic surfactant, which is necessary to prevent adsorption of adenovirus vaccine to glass surfaces of the inside of the vial during storage.
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